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KMID : 0896219910120010697
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Journal of Daegu Health College
1991 Volume.12 No. 1 p.697 ~ p.707
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Synthesis and Antimicrobial Activity of 7-Hydroxy-2-aminophenazine-5, 10-dioxide from 4-metnoxyaniline
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Han Sung-Wook
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Abstract
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7-Hydroxy-2-aminophenazine-5,10-dioxide was synthesized from 4-aminophenol and 6-hydroxiben-zofuroxan was previously obtained through various reaction steps starting from 4-methoxyaniline. All the intermediates and final product were purified by way of recrystallization, and extraction, and were identified by using IR and NMR spectrophotometer. Amtimicrobial activity of phenazine dioxide derivative was also determined for some Gram positive and negative bacteria.
It was observed that 7-hydroxy-2-aminophenazine-5 10-dioxide was stronger antimicrobial activity against both Gram positive and negative microbes than phenazine dioxides bearing methoxy, methyl, hydrogen, acetyl and nitro groups. From the result of this study, it might be concluded that electron density of the oxygen on N→O bond.
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